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Candida auris: what have we learned so far?
Gabriela Corsi-Vasquez1, Luis Ostrosky-Zeichner2
1Infectious Diseases Department, Hillcrest Medical Center, Tulsa, Oklahoma.
Purpose Of Review:
The increasing prevalence of fungal infections due to Candida species has been well described in critically ill patient populations, but in recent years a new species, Candida auris has received attention from the medical community worldwide. We aim to summarize the current knowledge related to C. auris, as new identification techniques, novel antifungal agents and more experience with outbreak management have been published in the past few years.
Recent Findings:
C. auris has been described in several countries, arising independently in separate clades. Its resistance to multiple antifungals and persistent colonization of patients and medical surfaces have become a therapeutic and infection control challenge. Recent elucidation of some of the molecular mechanisms related to pathogenicity and studies of in-vitro efficacy of novel antifungal agents can better guide therapy.
Summary:
As C. auris continues to cause outbreaks worldwide, newer, and more efficient identification techniques, novel antifungals, and more knowledge in effective infection control techniques will allow better clinical outcomes in the management and control of invasive fungal disease.
Insights
Candida auris, a multidrug-resistant fungus, poses a global health challenge. Understanding its spread, resistance, and effective management is crucial for controlling invasive fungal infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Public Health
Background:
- Increasing prevalence of Candida species infections in critically ill patients.
- Emergence of Candida auris as a global health concern due to its unique characteristics.
- Need for updated knowledge on Candida auris due to recent advancements.
Purpose of the Study:
- To summarize current knowledge on Candida auris.
- To review new identification techniques for Candida auris.
- To discuss novel antifungal agents and outbreak management strategies for Candida auris.
Main Methods:
- Literature review of recent publications on Candida auris.
- Analysis of data on identification, antifungal resistance, and pathogenicity.
- Synthesis of information on infection control and therapeutic approaches.
Main Results:
- Candida auris exhibits independent clades and widespread geographic distribution.
- Multidrug resistance and persistent colonization present significant therapeutic and infection control challenges.
- Elucidation of molecular mechanisms and in-vitro studies of novel antifungals offer potential guidance for therapy.
Conclusions:
- Continued global outbreaks of Candida auris necessitate improved identification methods.
- Development of novel antifungal agents is essential for effective treatment.
- Enhanced knowledge of infection control techniques is vital for managing invasive Candida auris disease.
