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Candida auris: what have we learned so far?
Gabriela Corsi-Vasquez1, Luis Ostrosky-Zeichner2
1Infectious Diseases Department, Hillcrest Medical Center, Tulsa, Oklahoma.
Current Opinion in Infectious Diseases
|October 9, 2019
Summary
Candida auris, a multidrug-resistant fungus, poses a global health challenge. Understanding its spread, resistance, and effective management is crucial for controlling invasive fungal infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Public Health
Background:
- Increasing prevalence of Candida species infections in critically ill patients.
- Emergence of Candida auris as a global health concern due to its unique characteristics.
- Need for updated knowledge on Candida auris due to recent advancements.
Purpose of the Study:
- To summarize current knowledge on Candida auris.
- To review new identification techniques for Candida auris.
- To discuss novel antifungal agents and outbreak management strategies for Candida auris.
Main Methods:
- Literature review of recent publications on Candida auris.
- Analysis of data on identification, antifungal resistance, and pathogenicity.
- Synthesis of information on infection control and therapeutic approaches.
Main Results:
- Candida auris exhibits independent clades and widespread geographic distribution.
- Multidrug resistance and persistent colonization present significant therapeutic and infection control challenges.
- Elucidation of molecular mechanisms and in-vitro studies of novel antifungals offer potential guidance for therapy.
Conclusions:
- Continued global outbreaks of Candida auris necessitate improved identification methods.
- Development of novel antifungal agents is essential for effective treatment.
- Enhanced knowledge of infection control techniques is vital for managing invasive Candida auris disease.
