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Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases

Marie Ito1, Tetsuhiro Tanaka, Masaomi Nangaku

  • 1Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Current Opinion in Nephrology and Hypertension
|October 9, 2019
PubMed
Abstract

Insights

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular homeostasis. Novel insights into Nrf2

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor critical for cellular homeostasis.
  • Emerging evidence highlights complex internal regulatory mechanisms governing Nrf2 activity.
  • Nrf2 plays a broader role in cellular defense than previously understood.

Purpose of the Study:

  • To review novel findings on Nrf2's internal regulatory mechanisms.
  • To explore the expanding understanding of Nrf2's role in maintaining cellular homeostasis.
  • To discuss the clinical applications of Nrf2 activators.

Main Methods:

  • Review of recent scientific literature on Nrf2.
  • Analysis of studies investigating Nrf2 regulatory pathways.
  • Examination of clinical trial data for Nrf2 activators.

Main Results:

  • Elucidation of Nrf2's internal regulatory mechanisms.
  • Discovery of new Nrf2-regulated pathways, including defense against ferroptosis.
  • Several Nrf2 activators are in clinical trials for chronic kidney diseases (CKD).

Conclusions:

  • Nrf2 is a crucial factor in cellular stress response and homeostasis.
  • Nrf2 activators show promise for treating chronic diseases linked to oxidative stress and inflammation.
  • Ongoing research aims to establish Nrf2 as a therapeutic target for conditions like CKD.

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