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Bone Conditioned Medium: Preparation and Bioassay
Published on: July 8, 2015
The Effect of Bone Marrow Aspirate Concentrate Application on Distracted Bone Biomechanical Properties
Yasser Nabil El Hadidi1, Mohamed Seif2, Heba Sleem1
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University.
Background:
This study was conducted to assess effect of bone marrow aspirate concentrate (BMAC) on enhancing biomechanical properties of distraction osteogenesis (DO).
Methods:
Twelve rami of goats had distraction and were divided into test group (DO bone supplemented with BMAC) and control group.
Results:
Assessment of bone-width showed nonsignificant (P = 0.9) increase in test group (mean = 5.3 mm, standard deviation = 1.9 mm) compared to control group (mean = 5.2 mm, standard deviation = 0.8 mm). Assessment of radiographic density showed nonsignificant (P = 0.5) increase in test group (mean = 163.4 Hounsfield Unit, standard deviation = 6.5 Hounsfield Unit) compared to control group (mean = 156.6 Hounsfield Unit, standard deviation = 21.8 Hounsfield Unit). Histomorphometry of mature-bone % showed significant (P = 0.02) increase in test group (mean = 30%, standard deviation = 9.8%) compared to control group (mean = 15.9%, standard deviation = 7.2%). Assessment of biomechanical testing (bone strength) by 3-point bending test showed nonsignificant (P = 0.7) increase in test group (mean = 511.6 Newton, standard deviation = 189.1 Newton) compared to control group (mean = 467.8 Newton, standard deviation = 201.1 Newton).
Conclusion:
The BMAC failed to improve both bone quantity and biomechanical bone strength of distracted bone.
