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Acute Pancreatitis Associated With Cytarabine During the Treatment of Pediatric Acute Myeloid Leukemia

Farhan Murshed1, Victor Wong2, Jeffrey L Koning3

  • 1Departments of Pediatrics.

Journal of Pediatric Hematology/Oncology
|October 9, 2019
PubMed

Insights

Pediatric pancreatitis is a known side effect of several cancer drugs. This case highlights cytarabine as a potential cause of pancreatitis in children undergoing leukemia treatment.

Area of Science:

  • Pediatric Oncology
  • Gastroenterology
  • Hematology

Background:

  • Pancreatitis is a recognized adverse event associated with various pediatric chemotherapy agents.
  • Commonly implicated drugs include asparaginase, pentamidine, mercaptopurine, corticosteroids, and trimethoprim-sulfamethoxazole.

Observation:

  • A 10-year-old female patient diagnosed with acute myeloid leukemia experienced pancreatitis.
  • The patient was undergoing treatment that included the chemotherapy agent cytarabine.

Findings:

  • This case report identifies cytarabine as a potential cause of pancreatitis in pediatric patients with acute myeloid leukemia.
  • Cytarabine-induced pancreatitis is underreported in pediatric oncology literature.

Implications:

  • Clinicians should consider cytarabine as a potential etiology for pancreatitis in pediatric leukemia patients.
  • Further investigation into the incidence and mechanisms of cytarabine-associated pancreatitis is warranted.

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