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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

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Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

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Published on: January 12, 2024

Orbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular Glaucoma.

Khalid M Aldaas¹, Cara Randall², Kian Eftekhari¹

¹Department of Ophthalmology.

Ophthalmic Plastic and Reconstructive Surgery

|October 9, 2019

Summary

Diffuse large B-cell lymphoma (DLBCL) can rapidly cause vision loss. This case highlights DLBCL in the optic nerve presenting as neovascular glaucoma, a previously unreported presentation.

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Area of Science:

Ophthalmology
Oncology
Pathology

Background:

Orbital lymphomas, often marginal-zone B-cell lymphomas, account for approximately 1% of non-Hodgkin lymphomas.
Diffuse large B-cell lymphoma (DLBCL) is the second most common type of orbital lymphoma and can lead to rapid vision loss if untreated.

Observation:

A patient presented with sudden, severe vision loss.
Examination revealed rubeosis iridis, hyphema, neovascular glaucoma, and vitreous hemorrhage.
A medical history of systemic DLBCL was noted, and an orbital mass in the optic nerve was identified.

Findings:

Optic nerve biopsy confirmed diffuse large B-cell lymphoma.
This presentation of neovascular glaucoma secondary to an extraocular DLBCL is, to the authors' knowledge, unprecedented.

Implications:

Early diagnosis and treatment of orbital lymphomas are crucial to prevent irreversible vision loss.
This case expands the known clinical presentations of orbital DLBCL, emphasizing the importance of considering lymphoma in the differential diagnosis of neovascular glaucoma.