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Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysis
Fang-Ying Wang1,2, Ching-Chi Chi1,2
1Department of Dermatology, Chang Gung Memorial Hospital, Linkou.
Abstract:
Rosacea has been reported with several systemic comorbidities, but its relationship with inflammatory bowel disease (IBD) is unclear. Thus, our objective is to conduct a meta-analysis on the association of rosacea with IBD.We conduct a meta-analysis and searched MEDLINE, CENTRAL, and Embase databases for case-controlled and cohort studies that assessed the association of rosacea with IBD from inception to July 2nd, 2018. Two authors independently selected studies, extracted data, and assessed the risk of bias of included studies. Disagreement was resolved by discussion. We performed random-effects model meta-analysis to obtain the pooled risk estimates for Crohn disease (CD) and ulcerative colitis (UC) in patients with rosacea.We included three case-control and three cohort studies. The risk of bias of included studies was generally low. The meta-analysis on case-control studies showed marginally increased odds of CD (pooled odds ratio (OR) 1.30, 95% confidence interval (CI) 0.99-1.69) and a significantly increased odds of UC (pooled OR 1.64, 95% CI 1.43-1.89) in patients with rosacea. The meta-analysis on cohort studies demonstrated significant increased risk of CD (pooled hazard ratio (HR) 1.58, 95% CI 1.14-2.20) and UC (pooled HR 1.18, 95% CI 1.01-1.37) in patients with rosacea.The evidence indicates an association of rosacea with IBD. If patients with rosacea suffer from prolonged abdominal pain, diarrhea, and bloody stool, referral to gastroenterologists may be considered.
Insights
This study found a significant association between rosacea and inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis. Patients with rosacea experiencing gastrointestinal symptoms may benefit from gastroenterologist referral.
Area of Science:
- Dermatology
- Gastroenterology
- Epidemiology
Background:
- Rosacea is a common inflammatory skin condition.
- Several systemic comorbidities are linked to rosacea, but its association with inflammatory bowel disease (IBD) remains unclear.
Purpose of the Study:
- To conduct a meta-analysis investigating the association between rosacea and IBD.
- To determine the risk of Crohn disease (CD) and ulcerative colitis (UC) in patients with rosacea.
Main Methods:
- Searched MEDLINE, CENTRAL, and Embase for case-controlled and cohort studies up to July 2018.
- Performed random-effects model meta-analysis to pool risk estimates.
- Assessed risk of bias for included studies.
Main Results:
- Meta-analysis of case-control studies showed increased odds of UC (OR 1.64) and marginally increased odds of CD (OR 1.30) in rosacea patients.
- Meta-analysis of cohort studies revealed a significant increased risk of CD (HR 1.58) and UC (HR 1.18) in rosacea patients.
- Included studies generally had a low risk of bias.
Conclusions:
- Evidence indicates a significant association between rosacea and IBD.
- Consider gastroenterologist referral for rosacea patients with persistent gastrointestinal symptoms like abdominal pain, diarrhea, or bloody stool.
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