Nippostrongylus brasiliensis infection can induce IgE production in rnu/rnu rats

Although rnu/rnu homozygous athymic rats are generally considered to be entirely deficient in mature T cells and unable to produce any T-cell-dependent immune response, we were able to induce slight IgE production in some Nude rats after Nippostrongylus brasiliensis infection. This report stresses the importance of taking the greatest care in the use of congenitally athymic rnu/rnu rats, as strong stimulation can, in some individuals, induce reactions which are generally considered to be T-cell-dependent. Hypotheses explaining this phenomenon are suggested.