Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suppressor-cell functions in bullous pemphigoid.

A R Ahmed

    Archives of Dermatological Research
    |January 1, 1985
    PubMed
    Summary

    This study found no significant differences in T cell function in bullous pemphigoid patients. Immunoregulatory defects, if present, are highly specific and require antigen-specific assays.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pemphigoid of the pulmonary system.

    Annales de dermatologie et de venereologie·2024
    Same author

    Association of HMGBP1 expression with clinical periimplant parameters among smokers and never-smokers with and without peri-implantitis.

    European review for medical and pharmacological sciences·2022
    Same author

    Assessment of radiographic morphology of mandibular condyles: a radiographic study.

    Folia morphologica·2021
    Same author

    Simple tool to prioritize access to bariatric surgery for people living with obesity during the COVID-19 pandemic.

    The British journal of surgery·2021
    Same author

    Should Oral Sodium Bicarbonate Be Used to Prevent Chronic Kidney Disease Progression?

    Irish medical journal·2020
    Same author

    Tracking physical activity using smart phone apps: assessing the ability of a current app and systematically collecting patient recommendations for future development.

    BMC medical informatics and decision making·2020

    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Bullous pemphigoid (BP) is an autoimmune blistering disease.
    • The role of T cell immunoregulatory function in BP pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate T cell phenotypes and functions in patients with bullous pemphigoid.
    • To determine if altered helper or suppressor T cell activity contributes to the disease.

    Main Methods:

    • Flow cytometry using Leu-1, Leu-2, and Leu-3 antibodies to analyze T cell populations.
    • In vitro IgG synthesis assay using peripheral blood leukocytes (T and B cells) from patients and healthy controls.
    • Functional assessment of T cell suppressor activity via irradiation before co-culture with B cells.

    Main Results:

    • No significant differences in the proportions of total T cells, helper T cells, or suppressor T cells in the peripheral blood of BP patients compared to normal subjects.
    • No significant differences in total IgG synthesis when B cells were cultured with T cells (untreated or irradiated) from BP patients or controls.
    • T cell suppressor function, as assessed by IgG synthesis, was not found to be impaired in BP patients.

    Conclusions:

    • The study suggests no generalized loss of suppressor T cell function or increased helper T cell function in bullous pemphigoid.
    • The findings indicate that any immunoregulatory defect in BP is likely highly specific and may require antigen-specific assays for detection.

    Related Experiment Videos