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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
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Morphological features of tooth development and replacement in the rabbit Oryctolagus cuniculus
Ludivine Bertonnier-Brouty1, Laurent Viriot1, Thierry Joly2
1Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Archives of Oral Biology
|October 9, 2019
Summary
The European rabbit (Oryctolagus cuniculus) offers new insights into mammalian tooth replacement. Researchers detailed its dental development and replacement, identifying a novel repair mechanism in newborn rabbits.
Area of Science:
- Developmental Biology
- Comparative Anatomy
- Mammalian Dentistry
Background:
- Mammalian dental development is primarily studied in mice, which lack tooth replacement.
- Understanding tooth replacement is crucial for regenerative dentistry and evolutionary biology.
- The European rabbit (Oryctolagus cuniculus) presents a potential model for studying tooth replacement.
Purpose of the Study:
- To establish the European rabbit as a novel model for studying mammalian tooth replacement.
- To provide a comprehensive description of dental development and replacement chronology in rabbits.
- To investigate unique dental features in newborn rabbits.
Main Methods:
- Utilized 3D-reconstructions and histological sections for detailed analysis.
- Documented the histo-morphological chronology of dental development and replacement.
- Observed and described dentin structures and repair mechanisms in newborns.
Main Results:
- A complete histo-morphological chronology of dental development and replacement in rabbits was established.
- Identified and described holes in the dentin of newborn rabbits that open into the pulp cavity.
- Observed rapid dentin apposition by odontoblasts to repair these openings.
Conclusions:
- The European rabbit (Oryctolagus cuniculus) is a suitable model for studying mammalian tooth replacement.
- The observed repair mechanism provides new data on dentin regeneration.
- This study enhances our understanding of dental morphogenesis and replacement across mammals.
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