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CD Spectroscopy to Study DNA-Protein Interactions
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cGAS and CD-NTase enzymes: structure, mechanism, and evolution.

Philip J Kranzusch1

  • 1Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Current Opinion in Structural Biology
|October 9, 2019
PubMed
Summary

Cyclic GMP-AMP synthase (cGAS) and its homologs form a widespread enzyme family (CD-NTase) that synthesizes diverse RNA signals. These enzymes, found across biology, are crucial for cellular responses to environmental changes.

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