Duration of adoptively transferred dengue virus-induced suppressor activity

Dengue virus-induced suppressor pathway involves three sequential generations of suppressor T cells and their products. The present study was undertaken to determine the duration of suppressor activity of the different components of the suppressor pathway on adoptive transfer in recipient mice. It was observed that the suppressor activity of TS1 cells lasts for 21 days, of TS2 for 15 days, of SF for 7 to 10 days and of SF2 for 7 days. The duration of suppression appears to depend upon the length of suppressor pathway to be followed by each component.