Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with

Flemming J Olsen1, Louisa M Christensen2, Derk W Krieger3,4

  • 1Cardiovascular Non-Invasive Imaging Research Laboratory (CIRL), Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. flemming.j.olsen@gmail.com.

Insights

Left atrial strain (LAs) can help identify paroxysmal atrial fibrillation (PAF) in cryptogenic stroke patients. Impaired LAs independently predicts PAF, improving risk stratification beyond conventional echocardiography.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Stroke Neurology

Background:

  • Cryptogenic strokes (CS) are often caused by paroxysmal atrial fibrillation (PAF).
  • Early detection of PAF is crucial for stroke prevention.
  • Echocardiography can aid in identifying patients at risk for PAF.

Purpose of the Study:

  • To evaluate the predictive value of left atrial (LA) strain for identifying PAF in CS patients.
  • To assess a revised diastolic dysfunction (DDF) model incorporating LA strain for PAF prediction.

Main Methods:

  • Prospective study of 56 CS patients with cardiac monitoring.
  • Echocardiography including global longitudinal strain (GLS) and LA reservoir strain (LAs) was performed.
  • Patients were stratified by LAs, and a revised DDF grading was applied.

Main Results:

  • No conventional echocardiographic parameters predicted PAF.
  • Lower LAs was significantly associated with PAF (p=0.046) and independently predicted PAF (OR 5.88).
  • Revised DDF grading, but not conventional DDF, significantly predicted PAF (OR 1.88).

Conclusions:

  • Left atrial strain (LAs) is a valuable independent predictor of PAF in CS patients.
  • LAs improves risk stratification for PAF detection.
  • A revised DDF model incorporating LAs enhances PAF prediction in CS patients.

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