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Updated: Jan 6, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with
Flemming J Olsen1, Louisa M Christensen2, Derk W Krieger3,4
1Cardiovascular Non-Invasive Imaging Research Laboratory (CIRL), Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. flemming.j.olsen@gmail.com.
Insights
Left atrial strain (LAs) can help identify paroxysmal atrial fibrillation (PAF) in cryptogenic stroke patients. Impaired LAs independently predicts PAF, improving risk stratification beyond conventional echocardiography.
Area of Science:
- Cardiology
- Medical Imaging
- Stroke Neurology
Background:
- Cryptogenic strokes (CS) are often caused by paroxysmal atrial fibrillation (PAF).
- Early detection of PAF is crucial for stroke prevention.
- Echocardiography can aid in identifying patients at risk for PAF.
Purpose of the Study:
- To evaluate the predictive value of left atrial (LA) strain for identifying PAF in CS patients.
- To assess a revised diastolic dysfunction (DDF) model incorporating LA strain for PAF prediction.
Main Methods:
- Prospective study of 56 CS patients with cardiac monitoring.
- Echocardiography including global longitudinal strain (GLS) and LA reservoir strain (LAs) was performed.
- Patients were stratified by LAs, and a revised DDF grading was applied.
Main Results:
- No conventional echocardiographic parameters predicted PAF.
- Lower LAs was significantly associated with PAF (p=0.046) and independently predicted PAF (OR 5.88).
- Revised DDF grading, but not conventional DDF, significantly predicted PAF (OR 1.88).
Conclusions:
- Left atrial strain (LAs) is a valuable independent predictor of PAF in CS patients.
- LAs improves risk stratification for PAF detection.
- A revised DDF model incorporating LAs enhances PAF prediction in CS patients.
Abstract:
Paroxysmal atrial fibrillation (PAF) may be the cause of a substantial part of cryptogenic strokes (CS). Echocardiography could assist risk stratification for PAF to select patients in need of prolonged rhythm monitoring. We aimed to assess the value of left atrial (LA) strain and a revised diastolic dysfunction (DDF) model with LA strain for predicting PAF. This was a prospective study of 56 CS patients who had a cardiac monitor implanted for 3 year monitoring for PAF, and an echocardiogram performed prior to monitoring. Conventional echocardiography, global longitudinal strain (GLS) and LA strain were performed. LA speckle tracking provided the LA reservoir strain (LAs). Patients were stratified into high versus low LAs by ROC curves (28.2%), and this cut-off was used to refine DDF grading. During follow-up of median 20 months, 13 (23%) patients were diagnosed with PAF. No conventional echocardiographic parameters differed between patients who developed PAF and those without PAF. However, LAs was significantly impaired in PAF patients (LAs: 30 vs. 27% for non-PAF and PAF, p = 0.046). Low LAs significantly predicted PAF independent of LA volume and GLS [OR 5.88 (1.30; 26.55), p = 0.021]. Revised DDF grading significantly predicted PAF, even when adjusted for the CHADS2 risk-score (OR 1.88 [1.01;3.50], per increase in DDF grade, p for trend = 0.047), which was not the case for conventional DDF grading. In conclusion, LAs associates with PAF independent of GLS and LA size, and may be used to improve the performance of DDF grading for identifying PAF in CS patients.
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