Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glycosaminoglycans in localized scleroderma (morphoea).

R Møller, J Serup, T Ammitzbøll

    Connective Tissue Research
    |January 1, 1985
    PubMed
    Summary

    Glycosaminoglycan (GAG) composition changes in localized scleroderma skin reveal increased hyaluronic acid in perilesional areas and decreased amounts in sclerotic zones, alongside elevated dermatan sulfate and chondroitin sulfate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Innovative biochemisurgical treatment for stabilisation of an end-stage chronic wound in a complex vascular compromized patient.

    International journal of surgery case reports·2023
    Same author

    Comparison of aerosol generation between electrocautery and cold dissection tonsillectomy.

    The Journal of laryngology and otology·2023
    Same author

    Burden of hospital-acquired SARS-CoV-2 infections in Germany: occurrence and outcomes of different variants.

    The Journal of hospital infection·2022
    Same author

    Sequels to tattoo removal by caustic products.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2018
    Same author

    MR scanning, tattoo inks, and risk of thermal burn: An experimental study of iron oxide and organic pigments: Effect on temperature and magnetic behavior referenced to chemical analysis.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
    Same author

    Electron-induced photon emission above the quantum cutoff due to time-energy uncertainty.

    Optics letters·2017

    Area of Science:

    • Dermatology
    • Biochemistry
    • Connective Tissue Research

    Background:

    • Localized scleroderma involves significant changes in skin connective tissue.
    • Glycosaminoglycans (GAGs) are crucial components of the extracellular matrix, influencing tissue structure and hydration.
    • Alterations in GAG composition are implicated in fibrotic processes.

    Purpose of the Study:

    • To analyze the specific composition of glycosaminoglycans (GAGs) in skin affected by localized scleroderma.
    • To compare GAG levels in sclerotic, perilesional, and uninvolved skin areas.
    • To understand the role of GAG changes in the pathogenesis of localized scleroderma.

    Main Methods:

    • Biopsies were collected from sclerotic, perilesional, and clinically uninvolved skin of eight localized scleroderma patients.
    • Quantification of different GAGs, including hyaluronic acid, dermatan sulfate, chondroitin 4/6 sulfate, and heparan sulfate.
    • Analysis of uronic acid and hexosamine concentrations.

    Main Results:

    • Hyaluronic acid concentration was elevated in perilesional areas (p<0.05) but decreased in sclerotic areas (p<0.01).
    • Dermatan sulfate increased in both perilesional (p<0.05) and sclerotic (p<0.01) areas.
    • Chondroitin 4/6 sulfate showed an increase in sclerotic areas (p<0.05), while heparan sulfate remained unchanged.
    • Total uronic acid and hexosamine levels did not significantly differ.

    Conclusions:

    • Localized scleroderma is characterized by distinct alterations in GAG composition.
    • The observed GAG changes correlate with the inflammatory and fibrotic processes occurring in the skin.
    • These findings contribute to understanding the molecular mechanisms underlying connective tissue remodeling in scleroderma.

    Related Experiment Videos