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Related Concept Videos

MicroRNAs01:22

MicroRNAs

23.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: Jan 6, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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MicroRNAs: Small molecules with a large impact on pre-eclampsia.

Maryam Hemmatzadeh1,2,3, Navid Shomali4, Yousef Yousefzadeh4

  • 1Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Cellular Physiology
|October 10, 2019
PubMed
Summary

MicroRNAs (miRNAs) are key players in biological processes and disease. This study examines their role in pre-eclampsia (PE), a serious pregnancy disorder, highlighting specific deregulated miRNAs like miR-210 and miR-155 as potential biomarkers.

Keywords:
microRNAplacentapre-eclampsiapregnancy

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Area of Science:

  • Molecular Biology
  • Genetics
  • Obstetrics

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs crucial for biological regulation.
  • Pre-eclampsia (PE) is a severe pregnancy disorder causing maternal and fetal mortality, often lacking early diagnostic markers.
  • Current understanding of PE pathogenesis, particularly placental abnormalities, remains incomplete.

Purpose of the Study:

  • To review recent findings on miRNA expression in pre-eclampsia.
  • To discuss the role of specific miRNAs, such as miR-210 and miR-155, in PE.
  • To explore the potential of miRNAs as diagnostic and prognostic biomarkers for pre-eclampsia.

Main Methods:

  • Literature review of recent investigations on pre-eclampsia and placental miRNA expression.
  • Analysis of studies focusing on the deregulation of specific miRNAs (e.g., miR-210, miR-155) in PE patients.
  • Synthesis of current knowledge regarding miRNA involvement in PE pathogenesis and biomarker potential.

Main Results:

  • Numerous studies indicate that miRNAs are significantly involved in pre-eclampsia.
  • Specific miRNAs, including miR-210 and miR-155, are consistently found to be deregulated in patients with PE.
  • miRNAs show promise as potential biomarkers for the early diagnosis and prognosis of pre-eclampsia.

Conclusions:

  • MicroRNAs play a critical role in the biological processes underlying pre-eclampsia.
  • Deregulation of specific miRNAs like miR-210 and miR-155 is a hallmark of PE.
  • Further research into placental miRNAs could lead to improved diagnostic and prognostic tools for pre-eclampsia.