Related Experiment Video
Updated: Jan 6, 2026
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Effect of endothelial dysfunction on the pathogenesis of urolithiasis in patients with metabolic syndrome
Ozgur Yazici1, Fehmi Narter2, Akif Erbin1
1Department of Urology, Haseki Traning and Research Hospital, Istanbul, Turkey.
Objective:
The aim of the present prospective clinical study was to investigate the possible effect of endothelial dysfunction in urolithiasis.
Methods:
The study included 92 patients older than 18 years. The patients were divided into 4 groups with 23 patients each as group 1: metabolic sydrome (MetS) (-) stone disease (SD) (-), group 2: MetS (-) SD (+), group 3: MetS (+) SD (-) and group 4: MetS (+) SD (+). C-reactive protein, homocysteine, uric acid, and creatinine levels were evaluated between the groups. Endothelial (dys)function was evaluated based on the brachial artery flow-mediated dilation (FMD) measurement.
Results:
The mean age was 41.9 ± 10.2 (range, 18-62) years. Mean FMD value was 15.9 ± 18.2% (range, 24.0-68.5%). A strong significant difference was found between group 1 and 2 (p < .001); group 1 and 3 (p < .001) and group 1 and 4 (p < .001) with regard to FMD.
Conclusion:
These results suggest that endothelial dysfunction plays an important role in the pathogenesis of urolithiasis in patients with MetS.
Related Concept Videos
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
01:30Urinary Tract Calculi III: Medical Management
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
01:28Urinary Tract Calculi I: Introduction
01:30Coronary Artery Disease I: Introduction
01:20Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...