Related Experiment Video

Updated: Jan 6, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.8K

CHA2DS2-VASc score and fibrinogen concentration in patients with atrial fibrillation

Karolina Semczuk-Kaczmarek1, Anna E Płatek1,2, Anna Ryś1

  • 11st Department of Cardiology, Medical University of Warsaw, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|October 10, 2019
PubMed

Insights

The CHA2DS2-VASc score in atrial fibrillation patients correlates with increased fibrinogen levels. This suggests blood parameters may offer a more objective measure of thromboembolic risk beyond clinical factors.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Biochemistry

Background:

  • Thromboembolic risk stratification is essential for guiding atrial fibrillation (AF) treatment.
  • Current guidelines rely on the CHA2DS2-VASc score, which uses clinical parameters.
  • The objectivity of the CHA2DS2-VASc score may be limited due to its lack of correlation with laboratory-assessed coagulation status.

Purpose of the Study:

  • To investigate the association between the CHA2DS2-VASc score and blood parameters in patients with atrial fibrillation.
  • To determine if laboratory coagulation markers correlate with clinical thromboembolic risk assessment in AF.

Main Methods:

  • A cohort of 266 patients with continuous AF undergoing catheter ablation was studied.
  • CHA2DS2-VASc scores were calculated for all participants.
  • Blood samples were collected to analyze coagulation parameters and red blood cell indices.

Main Results:

  • Patients with a CHA2DS2-VASc score of 0 exhibited significantly lower fibrinogen concentrations compared to those with a score ≥1 (285.6 vs 322.6 mg/dL, p=0.02).
  • A positive trend was observed between increasing CHA2DS2-VASc scores and mean fibrinogen concentration (p-trend=0.04).
  • Differences in red blood cell parameters were noted, with lower-risk patients showing lower red blood cell counts but higher hemoglobin and hematocrit levels.

Conclusions:

  • A higher CHA2DS2-VASc score is independently associated with elevated fibrinogen levels in AF patients.
  • Fibrinogen concentration may serve as a valuable laboratory marker for refining thromboembolic risk assessment in AF.
  • Further research is warranted to validate the role of fibrinogen in predicting thromboembolic events in AF.
Abstract

Keywords:
CHA2DS2-VASc scoreatrial fibrillationfibrinogenthromboembolic risk

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.3K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.3K

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
251
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
256
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.2K