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Persistent IgE-secreting cells which are refractory to T-cell control.
International Archives of Allergy and Applied Immunology
|January 1, 1985
Summary
Persistent immunoglobulin E (IgE) responses in high IgE-responder rats and mice involve radioresistant and T suppressor cell-resistant IgE-secreting cells. These cells reside in bone marrow and draining lymph nodes, impacting IgE synthesis regulation.
Area of Science:
- Immunology
- Cell Biology
- Allergy Research
Background:
- High immunoglobulin E (IgE) responses are implicated in allergic diseases.
- Understanding the cellular mechanisms regulating persistent IgE production is crucial.
Purpose of the Study:
- To investigate the nature and localization of cells responsible for sustained IgE secretion in high IgE-responder rodents.
- To explore the resistance of these cells to irradiation and T suppressor cells.
Main Methods:
- Utilized high IgE-responder rats and mice models.
- Employed the enzyme-linked immunosorbent assay (ELISA)-plaque technique.
- Investigated cellular resistance to x-irradiation and T suppressor cells.
Main Results:
- Identified IgE-secreting cells resistant to x-irradiation and T suppressor cells.
- Localized these persistent IgE-secreting cells within the bone marrow and lymph nodes draining the immunization site.
- Demonstrated the presence of these cells following parenteral immunization.
Conclusions:
- The findings suggest a distinct cellular population contributes to persistent IgE responses.
- These cells may play a role in the long-term regulation of IgE synthesis.
- Results provide a basis for further investigation into human IgE regulation.