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High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor

Ling-Juan Huang1,2,3, Ying Shen1, Ju Bai1

  • 1Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Acta Haematologica
|October 10, 2019
PubMed
Abstract

Insights

High expression of long noncoding RNA SNHG18 and SEMA5A indicates a poor prognosis for multiple myeloma (MM) patients. This finding suggests these genes could be potential biomarkers for MM progression and patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Expression Analysis

Background:

  • Multiple myeloma (MM) is a hematological malignancy characterized by uncontrolled plasma cell proliferation.
  • Understanding the molecular mechanisms underlying MM progression is crucial for developing effective therapeutic strategies.
  • Long noncoding RNAs (lncRNAs) and their target genes play significant roles in various cancers, including MM.

Purpose of the Study:

  • To investigate the expression levels of lncRNA SNHG18 and its potential target gene SEMA5A in multiple myeloma patients.
  • To explore the correlation between SNHG18 and SEMA5A gene expression and the clinical characteristics of MM.
  • To assess the relationship between SNHG18 and SEMA5A expression and the overall survival (OS) of MM patients.

Main Methods:

  • Analysis of gene expression in newly diagnosed MM, complete remission MM, refractory/relapse MM, and iron deficiency anemia control groups.
  • Utilized Real-time quantitative PCR (qPCR) to determine relative expression levels of SNHG18 and SEMA5A.
  • Statistical analysis of clinical features, staging systems (DS, ISS, R-ISS, mSMART), and overall survival in relation to gene expression levels.

Main Results:

  • SNHG18 and SEMA5A were found to be highly expressed in newly diagnosed MM patients.
  • Gene expression levels correlated significantly with established MM staging systems (DS, ISS, R-ISS, mSMART).
  • High co-expression of SNHG18 and SEMA5A was associated with significantly reduced overall survival (OS) and a positive correlation (r=0.709, p<0.01) between the two genes.

Conclusions:

  • Elevated expression of both SNHG18 and SEMA5A is linked to a poorer prognosis in multiple myeloma.
  • These genes may serve as potential biomarkers for predicting MM patient outcomes.
  • Further research into the functional roles of SNHG18 and SEMA5A in MM pathogenesis is warranted.
Keywords:
Multiple myelomaOverall survivalSEMA5ASNHG18

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