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Interactions between immune response to fungal infection and microRNAs: The pioneer tuners

Keyvan Pakshir1, Hamid Badali2,3, Sanam Nami4

  • 1Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Mycoses
|October 10, 2019
PubMed

Insights

Fungal infections pose a significant threat, especially to immunocompromised individuals. This review explores how microRNAs (miRNAs), regulators of gene expression, could be harnessed for immunotherapy against these dangerous infections.

Area of Science:

  • Immunology
  • Molecular Biology
  • Mycology

Background:

  • Fungal infections are a growing global health concern, causing life-threatening diseases and high healthcare costs.
  • Immune responses are critical in combating fungal pathogens, but immunocompromised patients face severe risks and high mortality rates.
  • MicroRNAs (miRNAs) are key regulators of gene expression and play a significant role in modulating immune responses.

Purpose of the Study:

  • To review the fundamental biology and mechanisms of microRNAs (miRNAs).
  • To examine the role of the immune response in fungal infections.
  • To investigate the intricate interactions between miRNAs and the immune system in the context of fungal pathogenesis.

Main Methods:

  • Literature review focusing on miRNA biogenesis and function.
  • Analysis of immune response mechanisms against fungal pathogens.
  • Scrutiny of existing research on miRNA-mediated regulation of immunity in fungal infections.

Main Results:

  • MicroRNAs (miRNAs) are small, non-coding RNAs that act as master regulators of gene expression.
  • The immune system's interaction with fungal pathogens is complex and crucial for infection outcome.
  • Evidence suggests a significant interplay between miRNAs and immune cells in controlling fungal infections.

Conclusions:

  • MicroRNAs (miRNAs) demonstrate potential as therapeutic targets for immunotherapy against fungal infections.
  • Further research into miRNA functions in immunity is essential for developing novel treatments.
  • miRNA-based strategies could offer a new avenue for managing life-threatening fungal diseases.
Keywords:
fungal infectionsfungi-miRNA interactionsimmune responsemiRNA regulationmiRNA-immune response interactions

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