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Associations Between Left Ventricular Structure, Function, and Cerebral Amyloid: The ARIC-PET Study.

Michelle C Johansen¹, Thomas H Mosley², David S Knopman³

¹From the The Johns Hopkins University School of Medicine, Baltimore, MD (M.C.J., D.F.W., R.F.G.).

|October 11, 2019

Summary

Cardiovascular disease markers, specifically left ventricular diameter, are linked to elevated beta-amyloid (Aβ) brain deposits, a key Alzheimer's pathology. This suggests a connection between heart health and Alzheimer's disease development.

Keywords:

cardiovascular disease dementia echocardiography florbetapir hypertension

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Published on: March 7, 2019

Area of Science:

Neurology
Cardiology
Gerontology

Background:

Cardiovascular disease is a known risk factor for cognitive decline.
The specific mechanisms linking cardiovascular disease to cognitive decline are not fully understood.
Alzheimer's disease is characterized by beta-amyloid (Aβ) pathology.

Purpose of the Study:

To investigate the association between subclinical cardiac structure and function echocardiogram indices and Aβ deposition in nondemented individuals.
To test the hypothesis that cardiac pathology markers correlate with Aβ brain burden.

Main Methods:

Three hundred six nondemented participants from the Atherosclerosis Risk in Communities Study were enrolled.
Participants underwent florbetapir positron emission tomography to assess Aβ deposition and 2D echocardiography for cardiac evaluation.
Multivariable logistic regression was used to analyze cross-sectional associations between echocardiogram markers and elevated Aβ.

Main Results:

An increased end-diastolic left ventricular diameter was significantly associated with doubled odds of elevated global cortical Aβ.
This association remained significant even when excluding participants with mild cognitive impairment.
The findings indicate a link between left ventricular structural changes and Aβ deposition.

Conclusions:

A significant association was found between a left ventricular structure marker and elevated Aβ deposition, as detected by positron emission tomography.
Further prospective research is needed to determine the temporal relationship between cardiac changes and amyloid deposition.