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Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
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Placental genotype affects early postpartum maternal behaviour.

Sarah Gardner1,2, Jennifer L Grindstaff1, Polly Campbell1,2

  • 1Department of Integrative Biology, Oklahoma State University, Stillwater, OK, USA.

Royal Society Open Science
|October 11, 2019
PubMed
Summary

Placental dysfunction in mice impairs maternal care, slowing pup retrieval and reducing nesting behavior. Continued exposure to pups alleviates these effects, highlighting the placenta's role in maternal priming.

Keywords:
Mus musculus domesticusMus spretusgenomic imprintinghybridmaternal primingpup retrieval

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Area of Science:

  • Reproductive biology
  • Neuroendocrinology
  • Behavioral neuroscience

Background:

  • The mammalian placenta provides endocrine signals crucial for initiating maternal care at birth.
  • While placental dysfunction's impact on offspring growth is known, its effect on maternal behavior in natural systems remains unstudied.

Purpose of the Study:

  • To investigate how placental dysregulation affects maternal and anxiety-like behaviors in mice.
  • To understand the role of placental endocrine signals in priming maternal care.

Main Methods:

  • Utilized a cross between *Mus musculus domesticus* and *Mus spretus* mouse species, resulting in undersized hybrid placentas with gene misexpression.
  • Quantified maternal and anxiety-like behaviors in females based on pregnancy type (conspecific vs. hybrid placenta).
  • Assessed pup ultrasonic vocalizations and maternal behavior/physiology post-parturition.

Main Results:

  • Mothers exposed to hybrid placentas showed slower pup retrieval and less nesting behavior compared to controls.
  • Anxiety-like behaviors were not affected by hybrid placenta exposure.
  • Deficits in maternal responsiveness were not linked to pup vocalizations or pup genotype after 24 hours postpartum.

Conclusions:

  • Placental dysregulation impairs maternal priming, leading to initial deficits in maternal responsiveness.
  • Prolonged exposure to pups can mitigate the negative effects of placental dysfunction on maternal behavior.
  • This study offers novel insights into how the placenta mediates mother-offspring interactions.