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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Prevention and Treatment of Cardiac Surgery Associated Acute Kidney Injury
Hao Cheng1,2, Jian-Zhong Sun3, Fu-Hai Ji1
1Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.
Aim Of Review:
Acute kidney injury (AKI) after cardiac surgery is a relatively common postoperative complication and is independently related to increased mortality and morbidity.
Method:
In this review, we will focus on risk factors of developing AKI, early detection by biomarkers and preventive strategies for AKI after adult cardiac surgery.
Recent Findings:
Many perioperative factors affect renal function and acute AKI following cardiac surgery. Novel biomarkers of kidney injury such as neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), cystatin C (CysC), have the potential to facilitate the early diagnosis of cardiac surgery associated AKI (CSA-AKI). Pharmacological interventions have been inconsistent to their efficacy, and to date, there is no compelling pharmacologic agent known to reduce the risk of AKI or treat established AKI.
Summary:
Preventive strategies of AKI focus on optimal perioperative management.
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