miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1
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Updated: Jan 6, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
Published on: June 7, 2016
Jun Chen1, Qiang Jiang2, Xue-Qin Jiang1
1Breast Tumor Department, 3rd Hospital of Nanchang, No. 2 Xiangshan South Road, Xihu District, Nanchang, Jiangxi, China.
Abstract:
The study aimed to investigate the regulatory effect of miR-146a in proliferation, invasion and migration of breast cancer and its possible mechanism via NM23-H1. The expression levels of miR-146a in breast cancer with different pathological classification were significantly increased, while the expression levels of NM23-H1 were significantly decreased, which were closely correlated. Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1. In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1.
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