Effect of a Formulation Containing Low-Dose Sodium Deoxycholate on Local Fat Reduction
Sang Hoon Park1, Mi Ri Hyun2, Sang Wha Kim3
1Department of Plastic Surgery, Id Hospital, Seoul, Republic of Korea.
Aesthetic Plastic Surgery
|October 11, 2019
Summary
A new low-dose deoxycholic acid (DCA) formula effectively reduces fat, matching older high-dose versions. Topical high-dose DCA also showed fat-reducing effects in mice, suggesting potential for improved protocols.
Area of Science:
- Biochemistry
- Dermatology
- Pharmacology
Background:
- Synthetic deoxycholic acid (DCA) is an FDA-approved injectable for submental fat reduction.
- Research is exploring new formulations and application methods for DCA.
Purpose of the Study:
- To evaluate the fat-reducing efficacy of a novel low-dose DCA formulation.
- To assess the effects of topical DCA application for fat dissolution.
Main Methods:
- Obese mice were treated with injected or topically applied DCA formulations (low-dose and high-dose).
- Evaluations included body weight changes, micro-CT imaging, body composition analysis, and histology.
Main Results:
- The low-dose DCA formulation demonstrated comparable efficacy to the high-dose version in reducing body weight and fat.
- Topical application of high-dose DCA showed promising fat-reducing effects, unlike the low-dose formulation.
- Histological analysis supported the observed fat reduction in treated areas.
Conclusions:
- Low-dose DCA formulations offer a potentially effective alternative for fat reduction.
- Further research into optimized high-dose DCA preparation and application is warranted to minimize adverse effects.
- Topical application of DCA presents a potential area for future development.
