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l-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients.

Takehiro Okabayashi¹, Kenta Sui¹, Takatsugu Mastumoto¹

¹Department of Gastroenterological Surgery, Kōchi Health Sciences Center, Kōchi, Japan.

JPEN. Journal of Parenteral and Enteral Nutrition

|October 11, 2019

Summary

Perioperative l-carnitine supplementation significantly improved recovery after liver surgery. Patients receiving l-carnitine showed faster normalization of key markers, reduced liver failure, and shorter hospital stays.

Keywords:

ammonia cancer l-carnitine liver surgery

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Area of Science:

Hepatology
Surgical Oncology
Nutritional Biochemistry

Background:

The role of perioperative l-carnitine in patients undergoing hepatectomy for liver cancer remains uncertain.
Evaluating short-term outcomes is crucial for optimizing post-surgical care.

Purpose of the Study:

To assess the efficacy of perioperative l-carnitine in patients undergoing liver cancer surgery.
To compare short-term outcomes between l-carnitine treated and untreated hepatectomized patients.

Main Methods:

Randomized controlled trial design.
Inclusion of patients with primary liver malignancies undergoing hepatectomy.
Comparison of perioperative l-carnitine supplementation versus standard care.

Main Results:

Faster restoration of serum ammonia, prothrombin time, and neutrophil count observed in the l-carnitine group.
Significantly lower incidence of grade B posthepatic liver failure in the l-carnitine group (20% vs 76%).
Reduced length of hospitalization for patients receiving l-carnitine.

Conclusions:

Perioperative l-carnitine treatment demonstrates superior outcomes compared to standard care.
l-Carnitine may play a key role in regulating liver injury and promoting repair.
l-Carnitine supplementation can lead to shorter postoperative hospital stays.