Fast Tract Anesthesia Using Isoflurane and Propofol During Off-pump Coronary Artery Bypass Graft Surgery

Area of Science:

• Cardiology
• Anesthesiology
• Cardiac Surgery

Background:

• Off-pump coronary artery bypass graft (OPCABG) surgery requires effective anesthesia.
• Fast-track anesthesia aims for rapid patient recovery and extubation.
• Evaluating myocardial protection is crucial in cardiac surgery.

Purpose of the Study:

• To compare the myocardial protective effects of isoflurane and propofol in fast-track anesthesia for OPCABG.
• To assess postoperative cardiac enzyme (Troponin-I) and liver enzyme levels.
• To evaluate the efficacy of fast-track anesthesia in OPCABG surgery.

Main Methods:

• A randomized study of 260 patients undergoing elective OPCABG.
• Patients received either isoflurane or propofol anesthesia with a target extubation within 6 hours.
• Troponin-I and liver enzymes were measured at multiple pre- and postoperative time points.

Main Results:

• No significant difference in Troponin-I levels was observed between the isoflurane and propofol groups.
• Both anesthetic agents provided comparable myocardial protection during and after OPCABG.
• Liver function assessments showed no significant variations between groups.

Conclusions:

• Fast-track anesthesia with isoflurane or propofol offers similar myocardial protection in OPCABG.
• Both agents are suitable for fast-track anesthesia in this patient population.
• Excellent overall outcomes were achieved with both anesthetic strategies.