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Correlation of serum vitamin A, D, and E with recurrent respiratory infection in children

J Zhang1, R-R Sun, Z-X Yan

  • 1Department of Pediatrics (I), Cangzhou Central Hospital, Cangzhou, P.R. China.aj97de@163.com.

European Review for Medical and Pharmacological Sciences
|October 11, 2019
PubMed

Insights

Low vitamin A, D, and E levels are linked to active recurrent respiratory infections (RRI) in children. Supplementing these vitamins may aid RRI recovery.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Immunology

Background:

  • Recurrent respiratory infections (RRI) pose a significant health challenge in children.
  • Serum vitamin levels are crucial for immune function and overall health.
  • Investigating the relationship between specific vitamin deficiencies and RRI activity is important for understanding disease progression.

Purpose of the Study:

  • To examine the correlation between serum vitamin A, D, and E levels and the incidence of RRI in pediatric patients.
  • To compare vitamin levels in children with active RRI, stable RRI, and healthy controls.

Main Methods:

  • Retrospective analysis of medical records from 422 children diagnosed with RRI.
  • Inclusion of 100 healthy children as a control group.
  • Quantification of serum vitamin A, D, and E using high-performance liquid chromatography (HPLC).

Main Results:

  • Children with active and stable RRI exhibited significantly lower serum levels of vitamins A, D, and E compared to healthy controls (p < 0.001).
  • The active RRI group showed significantly lower vitamin levels than the stable RRI group (p < 0.001).
  • Partial correlation analysis revealed positive correlations between vitamins A, D, and E in children with active RRI.

Conclusions:

  • Vitamin A, D, and E deficiency is associated with increased disease activity in pediatric RRI.
  • Dietary supplementation of vitamins A, D, and E may support the recovery and rehabilitation of children suffering from RRI.
Abstract

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