Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Context-Dependent Extinction and Return of Pavlovian Alcohol-Seeking Behavior in Male and Female Rats.

Alcohol, clinical & experimental research·2026
Same author

CO<sub>2</sub> Reactivity but Not CO<sub>2</sub>-Induced Orexin/c-Fos Colocalization Differentially Predicts Alcohol-Seeking Behaviour After Extinction and Retrieval-Extinction in Rats.

Addiction biology·2026
Same author

A rat model of oral hormonal contraception: Effects on drug preference and gonadal function.

Behavioral neuroscience·2025
Same author

Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin.

Environmental health perspectives·2024
Same author

Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.

Environmental health perspectives·2024
Same author

Cognitive effects of early life exposure to PCBs: Sex-specific behavioral, hormonal and neuromolecular mechanisms involving the brain dopamine system.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Jan 6, 2026

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
09:07

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

13.9K

Mapping the estrous cycle to context-specific extinction memory.

Emily N Hilz1, Ryan W Smith1, Yae Jin Hong2

  • 1Department of Psychology.

Behavioral Neuroscience
|October 11, 2019
PubMed
Summary
This summary is machine-generated.

Female rats show renewed appetitive behavior linked to their estrous cycle. Hormone levels during extinction, not testing, influence this renewal, particularly for food-approach behaviors.

More Related Videos

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
11:17

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Published on: August 24, 2012

36.1K
Place and Response Learning in the Open-field Tower Maze
08:31

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

10.8K

Related Experiment Videos

Last Updated: Jan 6, 2026

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
09:07

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

13.9K
Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
11:17

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Published on: August 24, 2012

36.1K
Place and Response Learning in the Open-field Tower Maze
08:31

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

10.8K

Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Animal Behavior

Background:

  • Pavlovian renewal paradigms typically fail to elicit appetitive behavior renewal in female rats.
  • Exogenous estradiol administration can induce renewal behavior in female rats.

Purpose of the Study:

  • To investigate the influence of the estrous cycle on appetitive behavior renewal in female rats.
  • To examine estrous cycle effects on brain activity supporting renewal.
  • To determine if the estrous cycle differentially affects renewal of distinct appetitive behaviors.

Main Methods:

  • Female rats were assessed for renewal behavior across different stages of their estrous cycle (proestrous, metestrous/diestrous).
  • Behavioral renewal was measured for approach to a food site and approach to a light cue.
  • FOS ( Fos ) protein expression was analyzed in key brain regions, including the hippocampus and amygdala.

Main Results:

  • Elevated renewal behavior was observed in rats in the proestrous stage during extinction compared to other stages.
  • This estrous cycle-dependent renewal effect was specific to conditioned approach behavior toward the food delivery site, not the light cue.
  • Differential FOS expression in the hippocampus and amygdala correlated with observed behavioral differences.

Conclusions:

  • Endogenous hormonal fluctuations across the estrous cycle modulate context information processing in female rats.
  • The encoding and retrieval of contextual information for appetitive behaviors are state-dependent, influenced by hormonal status.