A reminder that experimentally induced intermittent hypoxia is an incomplete model of obstructive sleep apnea and its outcome measures

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A Model to Simulate Clinically Relevant Hypoxia in Humans
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A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

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Jason H Mateika1,2,3

  • 1Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 11, 2019
PubMed
Abstract

No abstract available in PubMed .

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
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Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
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