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Antibacterial and antifungal two phenolic sesquiterpenes from Dysoxylum densiflorum
Ni Komang T Dharmayani1, Tsuyoshi Yoshimura2, Elvira Hermawati3
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Mataram University, Jalan Majapahit 62, Mataram 83125, Indonesia.
Abstract:
A new phenolic sesquiterpene, dysoxyphenol (1), and the known sesquiterpene, 7R,10S-2-hydroxycalamenene (2), were isolated from the acetone extract of Dysoxylum densiflorum seeds. The structures of these compounds were determined based on physical, Nuclear Magnetic Resonance, and mass spectral data. Both compounds were evaluated for their antibacterial and antifungal properties against seven pathogenic bacteria and two wood-rotting fungi, respectively. The results showed that both compounds have significant antibacterial properties only against Bacillus subtilis (Minimum Inhibitory Concentration 28 μM), while in the antifungal evaluation compound 1 was found to be more active than compound 2. Therefore, compound 1 has promising antifungal properties that can be developed further for finding new antifungal agents.
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