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RSV infection in Istanbul: risk factors and frequency

Elif İzci Güllü1, Yasemin Akın2, Ayşe Karaaslan3

  • 1Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey. elifizci@gmail.com.

Journal of Infection in Developing Countries
|October 11, 2019
PubMed

Insights

Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections (LRTI) in young children. This study found RSV in 19% of hospitalized infants, with higher rates in winter and among those under six months old.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections globally, particularly in children under two years old.
  • Hospitalized children under two with lower respiratory tract infections (LRTI) are a vulnerable population for RSV.
  • Limited regional data exists on the frequency and risk factors of RSV-associated LRTI.

Purpose of the Study:

  • To determine the frequency of RSV in hospitalized children under two years with LRTI.
  • To identify clinical features and risk factors associated with RSV infection in this cohort.
  • To provide regional data on RSV epidemiology and its correlation with meteorological conditions.

Main Methods:

  • A prospective study was conducted between September 2011 and May 2013.
  • Hospitalized children aged 0-2 years diagnosed with viral LRTI were included.
  • Nasopharyngeal secretions were tested for RSV antigen.

Main Results:

  • RSV antigen was detected in 19% (68/361) of the patients.
  • RSV infection peaked in December and January.
  • Risk factors for RSV positivity included age under 6 months, shorter breastfeeding duration, low socioeconomic status, and spontaneous vaginal delivery.
  • RSV-positive LRTI was associated with more severe disease compared to RSV-negative LRTI.

Conclusions:

  • This study provides crucial regional data on RSV frequency and associated risk factors.
  • Findings highlight the importance of considering RSV in hospitalized infants with LRTI, especially during winter months.
  • The study contributes to understanding RSV epidemiology and its link to meteorological factors in Turkey.
Abstract

Keywords:
IstanbulLRTIRSVTurkeychildrenrisk factor

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