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Related Experiment Video

Updated: Jan 6, 2026

Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava
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Persistent right umbilical vein in isomerism.

Ruben J Acherman1,2, William N Evans1,2

  • 1Children's Heart Center Nevada, Las Vegas, Nevada.

Prenatal Diagnosis
|October 11, 2019
PubMed
Summary

A persistent right umbilical vein is rare in normal situs solitus but common in isomerism. This finding is more frequent in right isomerism, prompting evaluation for isomeric conditions.

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Last Updated: Jan 6, 2026

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Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation
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Area of Science:

  • Medical Imaging
  • Fetal Development
  • Neonatal Health

Background:

  • The incidence of a persistent right umbilical vein (PRUV) is not well-established in fetuses with isomerism.
  • Situs solitus is the typical arrangement of visceral organs.

Purpose of the Study:

  • To determine the incidence of PRUV in fetuses with isomerism compared to those with situs solitus.
  • To assess the association between PRUV and specific types of isomerism (left vs. right).

Main Methods:

  • Retrospective, observational study of fetal echocardiography data from Southern Nevada (2006-2019).
  • Identified fetuses with confirmed right umbilical veins.
  • Compared PRUV incidence in situs solitus versus isomerism groups.

Main Results:

  • PRUV occurred in 0.5% of 16,320 fetuses with situs solitus.
  • Among 36 fetuses with isomerism, 15 (42%) had PRUV.
  • PRUV was more frequent in right isomerism (73%) than left isomerism (19%).

Conclusions:

  • A persistent right umbilical vein is rare in situs solitus but common in isomerism.
  • PRUV is significantly more prevalent in right isomerism, suggesting its utility as a marker.
  • Clinicians should consider checking for isomeric situs, particularly right isomerism, when a PRUV is detected.