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Reconstructing 3D proton dose distribution using ionoacoustics.

K W A van Dongen1,2, A J de Blécourt1, E Lens3

  • 1Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

Physics in Medicine and Biology
|October 11, 2019
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Summary
This summary is machine-generated.

This study shows ionoacoustic waves can monitor proton therapy dose distributions. This method accurately reconstructs 3D dose maps for isochronous cyclotrons and synchrocyclotrons during breast cancer treatment.

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Area of Science:

  • Medical Physics
  • Acoustic Imaging
  • Radiation Oncology

Background:

  • Proton therapy requires accurate dose monitoring for patient safety and treatment efficacy.
  • Current methods for measuring proton dose distribution during treatment are limited.
  • Ionoacoustic wave generation offers a potential non-invasive monitoring technique.

Purpose of the Study:

  • To investigate the feasibility of using ionoacoustic wave fields to monitor proton dose distributions.
  • To model and analyze the acoustic fields generated by proton beams in heterogeneous media.
  • To compare monitoring capabilities for isochronous cyclotrons and synchrocyclotrons.

Main Methods:

  • Numerical modeling of acoustic fields generated by 89 MeV proton beams.
  • Simulation of proton irradiation in a heterogeneous cancerous breast model.
  • Implementation of idealized temporal micro-structures for different accelerator types.
  • Application of model-based inversion techniques to reconstruct 3D dose distributions from simulated pressure fields.

Main Results:

  • Successful reconstruction of 3D proton dose distributions from simulated noisy ionoacoustic pressure fields.
  • Accurate localization of the maximum dose amplitude with low absolute error (5.0 mm for isochronous cyclotron, 5.2 mm for synchrocyclotron).
  • Demonstrated effectiveness for both isochronous cyclotron and synchrocyclotron beam characteristics.

Conclusions:

  • The ionoacoustic wave field shows significant potential for real-time monitoring of proton dose distributions.
  • This technique could enhance safety and effectiveness in proton therapy for breast cancer.
  • Further research and experimental validation are warranted.