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Na+/H+ exchanger and cardiac hypertrophy
1Centro de Investigaciones Cardiovasculares "Horacio E. Cingolani", Facultad de Ciencias Médicas, Universidad Nacional de La Plata - CONICET, Calle 60 y 120, 1900 La Plata, Argentina.
Hipertension Y Riesgo Vascular
|October 12, 2019
Summary
The Na+/H+ exchanger (NHE-1) hyperactivity switches cardiac hypertrophy to a pathological state. Strategies targeting NHE-1 hyperactivity can improve cardiovascular health by preventing maladaptive cardiac remodeling.
Area of Science:
- Cardiology
- Molecular Biology
- Physiology
Background:
- Reactive cardiac hypertrophy (CH) increases heart mass due to hemodynamic overload.
- Exercise-induced CH is adaptive, while pathological CH is a cardiovascular risk.
- The Na+/H+ exchanger (NHE-1) regulates intracellular pH and Na+.
Purpose of the Study:
- To review evidence linking NHE-1 hyperactivity to pathological cardiac hypertrophy.
- To explore NHE-1's role as a switch for the pathological phenotype in CH.
- To discuss strategies for avoiding NHE-1 hyperactivity to improve cardiovascular health.
Main Methods:
- Review of existing scientific literature on NHE-1 and cardiac hypertrophy.
- Analysis of the role of NHE-1 in intracellular ion homeostasis.
- Discussion of therapeutic strategies targeting NHE-1.
Main Results:
- NHE-1 hyperactivity, stimulated by neurohumoral factors and mechanical stress, causes Na+ overload.
- This overload activates prohypertrophic signaling pathways.
- NHE-1 hyperactivity is linked to ischemia-reperfusion injury, maladaptive CH, and heart failure.
Conclusions:
- NHE-1 hyperactivity acts as a critical switch for pathological cardiac hypertrophy.
- Targeting NHE-1 hyperactivity offers potential therapeutic benefits for cardiovascular diseases.
- Strategies to inhibit NHE-1 hyperactivity are crucial for maintaining cardiovascular health.
Keywords:
EstiramientoHipertrofiaHypertrophyIGF-1, ejercicioIGF-1, exerciseIntercambiador sodio/hidrógenoSodium hydrogen exchangerStretchingMore Related Videos
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