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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

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Age-Dependent Signal Intensity Changes in the Structurally Normal Pediatric Brain on Unenhanced T1-Weighted MR

T F Flood¹, P R Bhatt¹, A Jensen²

¹From the Departments of Radiology (T.F.F., P.R.B.).

AJNR. American Journal of Neuroradiology

|October 12, 2019

Summary

This study establishes age-dependent brain parenchymal signal intensity values in pediatric MRI scans. Increased age correlates with higher signal intensity, aiding in the interpretation of brain development and gadolinium deposition research.

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Area of Science:

Radiology and Imaging Science
Pediatric Neuroimaging
Quantitative MRI

Background:

Brain parenchymal signal intensity changes on T1-weighted MRI can indicate various conditions.
Quantitative data for age-related signal intensity in pediatric brains is limited.
Establishing normal values is crucial for accurate interpretation.

Purpose of the Study:

To determine age-dependent brain parenchymal signal intensity values.
To analyze these values in structurally normal pediatric brains (up to 18 years).
To provide a baseline for evaluating developmental changes and MRI artifacts.

Main Methods:

Retrospective analysis of 114 gadolinium-naïve pediatric patients.
Region of interest (ROI) signal intensity measurements in specific brain areas.
Multivariable linear regression to assess age and signal intensity correlation.

Main Results:

A significant association between increasing age and signal intensity was found in most tested neuroanatomic areas (P < .01).
No significant sex-based differences in signal intensity were observed.
The frontal gray matter was an exception, not showing this age-related trend.

Conclusions:

Age-dependent signal intensity parameters were established for normal pediatric brains on unenhanced T1WI.
Increased age correlates with increased signal intensity, excluding frontal gray matter.
These findings aid in understanding pediatric brain development, potential myelin/water content changes, and confounding effects in gadolinium deposition research.