Complete Genome Sequence of Proteus mirabilis Siphophage Saba
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Published on: July 18, 2025
James Nguyen1, Laith Harb1, Russell Moreland1
1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Abstract:
Proteus mirabilis is a Gram-negative enteric bacterium associated with complicated human urinary tract infections. Here, we present the complete genome annotation for P. mirabilis siphophage Saba. With a 60,056-bp genome and 75 predicted genes, Saba is most similar at the nucleotide and protein levels to phage Chi and Chi-like viruses.
Insights
Researchers fully annotated the genome of Proteus mirabilis siphophage Saba. This bacteriophage is genetically similar to Chi and other Chi-like viruses, offering insights into phage-host interactions.
Area of Science:
- Microbiology
- Virology
- Genomics
Background:
- Proteus mirabilis is a Gram-negative bacterium linked to complex human urinary tract infections.
- Bacteriophages are viruses that infect bacteria and play roles in microbial ecology and evolution.
Purpose of the Study:
- To provide a complete genome annotation for the P. mirabilis siphophage Saba.
- To characterize the genetic relationship of Saba to other known bacteriophages.
Main Methods:
- Whole-genome sequencing of Saba.
- Bioinformatic analysis for gene prediction and functional annotation.
- Comparative genomics to assess similarity with other phages.
Main Results:
- The Saba genome is 60,056 base pairs long.
- 75 protein-coding genes were predicted.
- Saba exhibits significant nucleotide and protein sequence similarity to phage Chi and Chi-like viruses.
Conclusions:
- The genome annotation provides a foundational resource for studying Saba.
- Saba's genetic similarity suggests shared ancestry or evolutionary pathways with Chi-like phages.
- Further research can explore Saba's role in P. mirabilis populations and its potential applications.
