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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

Sara B Noya1, David Colameo1, Franziska Brüning2,3

  • 1Institute of Pharmacology and Toxicology, University of Zürich, Zurich, Switzerland.

Science (New York, N.Y.)
|October 12, 2019
PubMed
Summary

Synaptic RNA transcripts in the brain exhibit daily rhythms, anticipating dawn and dusk. Sleep deprivation disrupts protein rhythms but not RNA, suggesting circadian control over synaptic needs.

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