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Acute Rabbit Eye Model for Testing Subretinal Prostheses.

Ying Xiao1, Yuqin Wang1, Fangting Li1

  • 1Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA.

Translational Vision Science & Technology
|October 12, 2019
PubMed
Summary
This summary is machine-generated.

This study demonstrates a two-step surgical technique for subretinal prostheses in rabbits, suitable for acute testing. However, the rabbit retina

Keywords:
rabbit eye modelacute visual electrophysiology eye modellongitudinal OCTretinal prosthesissubretinal implantation

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Retinal Prosthetics

Background:

  • Subretinal prostheses offer a novel approach to restoring vision in degenerative retinal diseases like retinitis pigmentosa and age-related macular degeneration.
  • Developing effective animal models is crucial for advancing the clinical translation of these vision-restoring technologies.

Purpose of the Study:

  • To characterize the surgical implantation technique for human subretinal prostheses in a rabbit eye model.
  • To determine the functional time window of this rabbit model for acute testing of subretinal prostheses.

Main Methods:

  • A two-step surgical technique was employed to implant subretinal prostheses in 26 rabbits.
  • Postoperative monitoring included fundus imaging, fluorescein angiography, and optical coherence tomography (OCT) for up to 21 days.

Main Results:

  • Successful implantation with good retinal apposition was achieved in 84.6% of rabbits.
  • OCT and histology revealed progressive retinal atrophy, with significant thinning by postoperative days 5-6.
  • The overlying retina maintained full thickness for the first 2 days, with intact inner layers until day 3.

Conclusions:

  • The two-step implantation technique is effective for acute subretinal prosthesis studies in rabbits.
  • Due to retinal characteristics and a limited time window, the rabbit model is unsuitable for chronic studies.
  • This technique enhances surgical efficacy in animal models, facilitating the transition to human clinical trials.