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Factors associated with exhaled nitric oxide in children with asthma and allergic rhinitis

Zheng Zhu1, Shu Xia2, Xi Chen1,3

  • 1Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

The Clinical Respiratory Journal
|October 12, 2019
PubMed

Insights

Fraction of exhaled nitric oxide (FeNO) levels in asthmatic children correlate with height and total IgE. FeNO is a better indicator of treatment response in older children using inhaled corticosteroid/long-acting beta-agonist (ICS/LABA).

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Biomarkers in Asthma

Background:

  • Limited data exists on factors influencing FeNO levels across different age groups in pediatric asthma.
  • Understanding these factors is crucial for accurate asthma management and monitoring.

Purpose of the Study:

  • To investigate factors associated with FeNO levels in asthmatic children aged 5-12 years.
  • To assess the FeNO response to inhaled steroid treatment across different pediatric age groups.

Main Methods:

  • Recruited 121 asthmatic children (5-12 years) with allergic rhinitis.
  • Measured FeNO, lung function, bronchial hyperresponsiveness, allergen-specific IgE, and blood eosinophils.
  • Assessed FeNO changes after 4 weeks of inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) treatment.

Main Results:

  • Higher FeNO levels were observed in older children (10-12 years) compared to younger groups.
  • Increased height and total IgE levels significantly correlated with higher FeNO.
  • ICS/LABA treatment improved asthma control in all groups, but FeNO reduction was significant only in older children.

Conclusions:

  • Height and total IgE are key correlates of FeNO in asthmatic children (5-12 years).
  • FeNO measurement is a more effective tool for evaluating ICS/LABA efficacy in older asthmatic children.
Abstract

Keywords:
allergyasthmachildrenfraction of exhaled nitric oxide (FeNO)

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