[Expert consensus statement on Diemailing~® Kudiezi Injection in clinical practice]

Area of Science:

• Cardiovascular Medicine
• Neurology
• Traditional Chinese Medicine

Background:

• Diemailing Kudiezi Injection (DKI) is widely used for cerebral infarction, coronary heart disease, and angina pectoris.
• Clinical evidence suggests DKI improves symptoms of cardiovascular and cerebrovascular diseases, yet it lacks inclusion in practice guidelines.
• Recent observations indicate potential misapplication of DKI in clinical settings.

Purpose of the Study:

• To establish an expert consensus guiding the appropriate clinical application of Diemailing Kudiezi Injection (DKI).
• To address concerns regarding the incorrect use of DKI in clinical practice.
• To provide a valuable reference for clinicians utilizing DKI.

Main Methods:

• Expert consensus compiled by nationwide cardiovascular and cerebrovascular disease specialists.
• GRADE system used for evidence quality grading based on outcomes and degrading factors.
• Nominal group method employed to formulate recommendations or consensus suggestions.
• Consideration of six factors: evidence quality, economy, efficacy, adverse reactions, patient acceptability, and others.

Main Results:

• Systematic and comprehensive summary of clinical indications, efficacy, and safety evidence for DKI.
• Evidence-based recommendations or consensus suggestions derived from rigorous evaluation.
• Preliminary data on DKI's performance were reviewed and integrated.

Conclusions:

• The expert consensus provides clear guidance on the clinical indications and use of DKI.
• Addresses the need for standardized and evidence-based application of DKI in treating cardiovascular and cerebrovascular diseases.
• Aims to improve patient outcomes by ensuring appropriate and effective utilization of DKI.