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[A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity]
Yan-Qi Sun1, Ling-Min Liao1, Xi Gao2
1College of Chemical and Environment,Yunnan Minzu University Kunming 650500,China Technology Center,China Tobacco Yunnan Industrial Co.,Ltd. Kunming 650106,China.
Abstract:
A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].
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