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Updated: Jul 3, 2026
11:10
High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
Drug-Resistant Salmonella typhi in Pakistan.
Christine E Petrin1, Russell W Steele1,2,3, Elizabeth A Margolis1,2,3
1Tulane University, New Orleans, LA, USA.
Clinical Pediatrics
|October 12, 2019
Summary
An extensively resistant strain of enteric fever (typhoid fever) has emerged in South Asia. This resistant typhi requires carbapenem antibiotics like meropenem for treatment, posing a challenge to public health.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Enteric fever, caused by Salmonella typhi or paratyphi, is a significant global health concern.
- Traditional treatments for enteric fever are becoming less effective due to emerging antibiotic resistance.
Observation:
- An outbreak of extensively resistant typhi (Salmonella typhi) occurred in Pakistan in early 2018.
- This strain is resistant to multiple common antibiotics, including third-generation cephalosporins, ampicillin, ciprofloxacin, trimethoprim-sulfamethoxazole, and chloramphenicol.
Findings:
- The extensively resistant typhi strain has infected thousands in South Asia and travelers globally, including cases in the United States.
- A case study highlights a child requiring broader antimicrobial treatment, specifically carbapenems like meropenem, for extensively resistant enteric fever acquired in Pakistan.
Implications:
- Clinicians must be aware of non-susceptibility to commonly recommended antibiotics in enteric fever cases.
- Extensively resistant typhi necessitates alternative treatment strategies, emphasizing the need for carbapenems or azithromycin.
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