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Frondoside A is a potential anticancer agent from sea cucumbers
1Department of Physiology, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
Abstract:
Cancer is a leading cause of death worldwide. Although high cure rates are achievable with current available drugs, this is not without side effects. Hence, attention has been shifted to alternative anticancer agents coming from natural products as treatment options. Extracts from marine sea cucumbers have been investigated for such properties. Frondoside A is a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, which has been used as a traditional remedy, recently, the extract was found to have potential anti-tumor properties. This narrative review aimed at critically analyzing and summarizing the literature available regarding Frondoside A anticancer properties. For that, scientific databases such as PubMed, EMBASE, and ScienceDirect were searched for the keywords; Frondoside A, cancer, metastasis, anticancer properties, and sea cucumbers. Articles in languages other than English were excluded from the study. Such review will help researchers to better tailor future experiments and will enrich the knowledge about natural compounds consumed as traditional substances.
Insights
Frondoside A, a natural compound from sea cucumbers, shows potential as an anticancer agent. This review summarizes its properties, offering insights for future cancer research and natural product development.
Area of Science:
- Marine Biology
- Pharmacology
- Oncology
Background:
- Cancer remains a leading global cause of mortality.
- Current cancer treatments have significant side effects.
- Natural products are being explored as alternative therapeutic options.
Purpose of the Study:
- To critically analyze and summarize existing literature on Frondoside A's anticancer properties.
- To consolidate research on Frondoside A derived from the sea cucumber Cucumaria frondosa.
- To provide a foundation for future research into natural anticancer agents.
Main Methods:
- A narrative review of scientific literature.
- Searches conducted in PubMed, EMBASE, and ScienceDirect databases.
- Keywords included Frondoside A, cancer, metastasis, anticancer properties, and sea cucumbers.
Main Results:
- Frondoside A, a glycoside from Cucumaria frondosa, exhibits potential anticancer properties.
- Literature suggests Frondoside A as a promising natural compound for tumor treatment.
- The review consolidates current understanding of its anti-tumor effects.
Conclusions:
- Frondoside A is a promising natural compound with anticancer potential.
- Further research is warranted to explore its efficacy and mechanisms.
- This review aids researchers in developing novel cancer therapies from natural sources.
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