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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

microRNAs in sudden hearing loss.

Desmond A Nunez^1,2,3, Printha Wijesinghe^1,2, Shahin Nabi^1,4

¹Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

The Laryngoscope

|October 12, 2019

Summary

This study identified eight specific microRNAs (miRNAs) that are differentially expressed in patients with sudden sensory neural hearing loss (SSNHL). These findings may reveal key cellular signaling pathways involved in auditory signal disruption.

Keywords:

Sudden sensorineural hearing loss microRNAs signaling pathways

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Area of Science:

Biochemistry
Genetics
Otolaryngology

Background:

Sudden sensory neural hearing loss (SSNHL) is a complex condition affecting auditory signal transmission.
Understanding the molecular mechanisms underlying SSNHL is crucial for developing effective treatments.

Purpose of the Study:

To compare circulating microRNA (miRNA) expression profiles between SSNHL patients and normal hearing controls.
To identify potential biomarkers and signaling pathways implicated in SSNHL pathogenesis.

Main Methods:

A prospective cohort multi-center study involving 36 SSNHL patients and 12 age-matched controls.
Circulating miRNA expression was analyzed using TaqMan Low Density Array on pooled sera.
Bioinformatic analyses were performed to identify target mRNAs and enriched signaling pathways.

Main Results:

Eight miRNAs (hsa-miR-590-5p, -186-5p, -195-5p, -140-3p, -128-3p, -132-3p, -375-3p, and -30a-3p) showed significant differential expression in SSNHL patients.
These miRNAs are predominantly found in the nervous system.
Putative target mRNAs were enriched in signaling pathways including PI3K/Akt, Ras, and MAPK.

Conclusions:

The identified miRNAs and associated signaling pathways offer insights into the molecular underpinnings of SSNHL.
These findings suggest potential therapeutic targets for restoring auditory function in SSNHL patients.