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TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases

Daisuke Matsumoto1, Hirokazu Tamamura1, Wataru Nomura1

  • 1Institute of Biomaterials and Bioengineering , Tokyo Medical and Dental University , 2-3-10 Kandasurugadai , Chiyoda-ku, Tokyo 101-0062 , Japan.

Biochemistry
|October 12, 2019
PubMed
Summary

Scientists developed a chemically inducible dimerization (CID) system for precise genome editing. This system uses rapamycin to control sequence-specific nucleases, enabling rapid and targeted DNA cleavage for mutation analysis.

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