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Sample Handling

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...

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An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

Managing hemolyzed samples in clinical laboratories.

Ana-Maria Simundic¹, Geoffrey Baird², Janne Cadamuro³

¹Department of Medical Laboratory Diagnostics, University Hospital "Sveti Duh", University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.

Critical Reviews in Clinical Laboratory Sciences

|October 12, 2019

Summary

This summary is machine-generated.

Hemolysis, a common lab error, disrupts red blood cells and affects test results. Standardizing detection and management of hemolyzed samples is crucial for accurate clinical laboratory medicine.

Keywords:

Hemolysis interference preanalytical phase standardization

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Area of Science:

Clinical Chemistry
Laboratory Medicine
Preanalytical Phase

Background:

Hemolysis, red blood cell membrane disruption, is the most common preanalytical error, causing over 60% of lab sample rejections.
It can occur in vivo (pathological) or in vitro (preventable), impacting laboratory assays through various interference mechanisms.

Purpose of the Study:

To provide a comprehensive overview of hemolysis, covering its causes, effects on clinical assays, and current management recommendations.
To highlight the need for standardization in detecting and managing hemolyzed samples in laboratory medicine.

Main Methods:

Review of existing literature and recommendations from the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for Preanalytical Phase (WG-PRE).
Discussion of interference mechanisms (spectrophotometric, component release, dilution, chemical) and assay methodology impact.
Analysis of current heterogeneous practices in hemolysis detection and management.

Main Results:

Hemolysis significantly impacts laboratory results, with interference degree dependent on hemolysis level and assay type.
Preanalytical practices for hemolysis management are inconsistent, necessitating standardization.
EFLM WG-PRE has issued recommendations on harmonizing automated assessment (hemolysis index) and managing hemolyzed samples.

Conclusions:

Standardization and quality improvement are essential to address the high prevalence and costs associated with hemolyzed blood samples.
Implementing EFLM WG-PRE recommendations can improve the accuracy and reliability of clinical laboratory testing.
Consistent management of hemolysis is vital given patient mobility and variations in healthcare practices.