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[Change in the immunological indices in arteriosclerosis]
Kardiologiia
|November 1, 1979
Summary
This study investigated immune responses in coronary atherosclerosis patients. Miscleron therapy normalized immune markers and improved lipid metabolism, unlike acetylsalicylic acid.
Area of Science:
- Immunology
- Cardiology
- Pharmacology
Background:
- Coronary atherosclerosis is linked to immune system alterations.
- Understanding T- and B-lymphocyte and immunoglobulin changes is crucial.
Purpose of the Study:
- To assess immune status in early coronary atherosclerosis.
- To evaluate the effects of miscleron and acetylsalicylic acid on immune markers and lipid metabolism.
Main Methods:
- Assessed T- and B-lymphocytes, immunoglobulins (G, A), and lymphocyte blast-cell transformation.
- Tested responses to aortic antigens in 59 patients and 23 controls.
- Administered miscleron to 23 patients and acetylsalicylic acid to 10 patients.
Main Results:
- Patients showed increased B-lymphocytes, immunoglobulins G and A, and heightened lymphocyte response to atherosclerotic aortic antigen.
- Atherosclerosis patients exhibited a trend towards decreased T-lymphocytes.
- Miscleron normalized immune indices and improved lipid metabolism.
- Acetylsalicylic acid had no significant effect on lipid metabolism or immunoglobulin levels.
Conclusions:
- Early coronary atherosclerosis involves specific immune system changes.
- Miscleron demonstrates therapeutic potential by modulating immune responses and lipid metabolism.
- Acetylsalicylic acid lacks these immunomodulatory and lipid-lowering effects in this context.