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[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus]
M Daniela Revilla Orías1, Xenia Alonso1, Jaume Campistol1
1Servicio de Neuropediatría Hospital Sant Joan de Déu, Barcelona, España.
Insights
Epilepsy affects nearly 30% of children with congenital hemiparesis (CH), often starting in infancy. Ischemic stroke increases epilepsy risk, necessitating early detection and treatment for better outcomes.
Area of Science:
- Neurology
- Pediatrics
- Epileptology
Background:
- Congenital hemiparesis (CH) is a common neurological condition in children.
- Epilepsy is a frequent comorbidity in children with CH, impacting their development and quality of life.
- Understanding the specific characteristics of epilepsy in this population is crucial for effective management.
Purpose of the Study:
- To determine the incidence and clinical presentation of epilepsy in children with CH.
- To identify risk factors and specific epilepsy syndromes associated with CH.
- To evaluate the efficacy of current antiepileptic treatments in this cohort.
Main Methods:
- A retrospective, descriptive, multicenter study.
- Data collected from clinical records of 310 children (0-19 years) with CH secondary to perinatal infarction in Catalonia.
- Analysis of epilepsy prevalence, seizure semiology, vascular stroke subtypes, and treatment responses.
Main Results:
- Epilepsy was diagnosed in 29.5% of children with CH.
- The most common vascular subtype was presumed perinatal ischemic stroke (51.3%).
- Motor focal seizures were most frequent (82%), with 67.3% controlled by monotherapy (valproate, levetiracetam, carbamazepine).
- Neonatal seizures occurred in 35% of those with epilepsy, and 30% of children with perinatal stroke and CH developed epilepsy.
- Children with ischemic stroke had the highest risk.
Conclusions:
- Approximately 30% of children with congenital hemiparesis develop epilepsy.
- Ischemic stroke is a significant risk factor for epilepsy in this population.
- Early detection and tailored follow-up are essential for managing epilepsy in children with CH, particularly those with ischemic stroke.
Abstract:
The objective was to describe the frequency, mode of presentation and characteristics of epilepsy in children with congenital hemiparesis (CH). It is a etrospective, descriptive and multicenter study, based on the collection of data from the clinical records of patients from 0 to 19 years with CH secondary to perinatal infarction in different centers of the community of Catalonia. A total of 310 children were included (55% males and 45% females), from a total of 13 centers in Catalonia. Average age of onset of the crises was 2 ± 1 year. Epilepsy was present in 29.5% (n = 76), among which the most frequent vascular subtype was arterial presumed perinatal ischemic stroke (51.3%), followed by neonatal arterial ischemic stroke (18.4%), periventricular venous infarction (15.8%), neonatal hemorrhagic stroke (10.5%) and neonatal cerebral sinovenous thrombosis (3.9%). Semiology of the most frequent seizures was motor focal in 82%, followed by focal motor with secondary bilateralization in 23%, focal discognitive in 13.5%, generalized by 2% and spasms in 6.5%. The 67.3% were controlled with monotherapy and the drugs used were valproate, levetiracetam or carbamazepine. The antecedent of electrical status during sleep was identified in 3 patients, all associated with extensive lesions that included the thalamus. Of the total number of children with epilepsy, 35% began with neonatal seizu res in the first 3 days of life. The 30% of children with perinatal stroke and CH present a risk of epilepsy during childhood. Children with ischemic strock have the highest risk, so they will require a follow-up aimed at detecting prematurely the epilepsy and start a treatment.
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