[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus]

M Daniela Revilla Orías1, Xenia Alonso1, Jaume Campistol1

  • 1Servicio de Neuropediatría Hospital Sant Joan de Déu, Barcelona, España.

Medicina
|October 12, 2019
PubMed

Insights

Epilepsy affects nearly 30% of children with congenital hemiparesis (CH), often starting in infancy. Ischemic stroke increases epilepsy risk, necessitating early detection and treatment for better outcomes.

Area of Science:

  • Neurology
  • Pediatrics
  • Epileptology

Background:

  • Congenital hemiparesis (CH) is a common neurological condition in children.
  • Epilepsy is a frequent comorbidity in children with CH, impacting their development and quality of life.
  • Understanding the specific characteristics of epilepsy in this population is crucial for effective management.

Purpose of the Study:

  • To determine the incidence and clinical presentation of epilepsy in children with CH.
  • To identify risk factors and specific epilepsy syndromes associated with CH.
  • To evaluate the efficacy of current antiepileptic treatments in this cohort.

Main Methods:

  • A retrospective, descriptive, multicenter study.
  • Data collected from clinical records of 310 children (0-19 years) with CH secondary to perinatal infarction in Catalonia.
  • Analysis of epilepsy prevalence, seizure semiology, vascular stroke subtypes, and treatment responses.

Main Results:

  • Epilepsy was diagnosed in 29.5% of children with CH.
  • The most common vascular subtype was presumed perinatal ischemic stroke (51.3%).
  • Motor focal seizures were most frequent (82%), with 67.3% controlled by monotherapy (valproate, levetiracetam, carbamazepine).
  • Neonatal seizures occurred in 35% of those with epilepsy, and 30% of children with perinatal stroke and CH developed epilepsy.
  • Children with ischemic stroke had the highest risk.

Conclusions:

  • Approximately 30% of children with congenital hemiparesis develop epilepsy.
  • Ischemic stroke is a significant risk factor for epilepsy in this population.
  • Early detection and tailored follow-up are essential for managing epilepsy in children with CH, particularly those with ischemic stroke.