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Berberine attenuates olanzapine induced-metabolic syndrome
Marwa Salih Al-Naimi1, Huda Abdulbaki Rasheed1, Hayder M Al-Kuraishy1
1Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.
Objective:
To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome.
Methods:
This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance, β- cell function and insulin sensitivity were evaluated.SPSS 20.
Results:
Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001.
Conclusions:
Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.
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