Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.9K
Overview
31.9K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Hypersensitivities01:30

Hypersensitivities

6.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.8K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

1.5K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.5K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

1.7K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Patch Testing in Clinical Practice: Insights From Amber Reck Atwater, MD.

Cutis·2026
Same author

Variations in Healthcare Provider Interactions and Treatment Satisfaction by Patient Race and Ethnicity: A Survey of Adults with Atopic Dermatitis.

Advances in therapy·2026
Same author

Comprehensive Patch Testing: An Essential Tool for Care of Allergic Contact Dermatitis.

Cutis·2026
Same author

Underutilization of patch testing for contact dermatitis: Insights from DataDerm.

Journal of the American Academy of Dermatology·2026
Same author

Lebrikizumab Improves Clinical Manifestations, Symptoms, and Quality of Life in Patients with Moderate-to-Severe Atopic Dermatitis Previously Treated with Dupilumab: Results from the ADapt Study.

Dermatology and therapy·2026
Same author

Lebrikizumab is efficacious in adults and adolescents with moderate-to-severe atopic dermatitis regardless of atopic comorbidities.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025

Related Experiment Video

Updated: Jan 5, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.7K

Methylisothiazolinone and isothiazolinone allergy.

Margo Reeder1, Amber Reck Atwater2

  • 1Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, USA.

Cutis
|October 12, 2019
PubMed
Summary

Methylisothiazolinone (MI) is a preservative causing allergic contact dermatitis (ACD) due to increased use in personal care products. Related chemicals like BIT and OIT are found in various products, with potential cross-reactivity to MI.

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.4K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K

Related Experiment Videos

Last Updated: Jan 5, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.7K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.4K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K

Area of Science:

  • Dermatology
  • Toxicology
  • Allergology

Background:

  • Methylisothiazolinone (MI) is a widely used preservative in water-based personal care products.
  • Increased concentrations of MI have been linked to a rise in allergic contact dermatitis (ACD).
  • MI allergy is primarily associated with personal care products but also occurs through household items, industrial chemicals, and paints.

Purpose of the Study:

  • To review Methylisothiazolinone (MI) and related isothiazolinone chemicals.
  • To discuss the sources of exposure and allergic reactions to MI.
  • To explore potential cross-reactivity with other isothiazolinones like Benzisothiazolinone (BIT) and Octylisothiazolinone (OIT).

Main Methods:

  • Literature review of Methylisothiazolinone (MI) and related isothiazolinones.
  • Analysis of exposure sources and clinical manifestations of MI allergy.
  • Examination of cross-reactivity patterns among isothiazolinones.

Main Results:

  • Personal care products are the primary source of MI contact allergy.
  • Other exposure sources include household products, industrial chemicals, paints, slime, and adhesives.
  • Benzisothiazolinone (BIT) and Octylisothiazolinone (OIT) are found in non-cosmetic products, with possible cross-reactivity to MI.

Conclusions:

  • The widespread use of MI has led to an increase in MI-induced allergic contact dermatitis.
  • Awareness of diverse exposure sources and potential cross-reactivity is crucial for managing isothiazolinone allergies.
  • Further research into the allergenic potential and cross-reactivity of isothiazolinones is warranted.